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Medication-Overuse Headache: Update on Management.

Prut Koonalintip1,2,3, Katherine Phillips4, Benjamin R Wakerley2,3

  • 1Division of Neurology, Department of Internal Medicine, Prince of Songkla University, Hatyai 90110, Songkhla, Thailand.

Life (Basel, Switzerland)
|September 28, 2024
PubMed
Summary
This summary is machine-generated.

Frequent use of acute pain relievers can worsen headaches, causing medication-overuse headache (MOH). New treatments offer hope for managing this condition, especially in migraine patients.

Keywords:
chronic migrainemedication-overuse headacherebound headache

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Long-term use of acute pain medication for headaches can paradoxically increase headache frequency.
  • Medication-overuse headache (MOH) is a significant issue, particularly for migraine patients using triptans and opioids.

Purpose of the Study:

  • To review the burden, development, pathophysiology, and treatment strategies for medication-overuse headache (MOH).

Main Methods:

  • This review examines existing literature on medication-overuse headache.
  • It synthesizes information on the epidemiology, mechanisms, and therapeutic approaches for MOH.

Main Results:

  • Prevention through education is key, but established MOH is challenging to treat.
  • Withdrawal of acute medication benefits most patients but is difficult to achieve.
  • OnabotulinumtoxinA, CGRP-targeted therapies, Gepants, and Ditans show promise for MOH and migraine management.

Conclusions:

  • Medication-overuse headache presents a complex clinical challenge.
  • Novel preventive and acute treatments, alongside educational strategies, are crucial for improving patient outcomes in MOH and migraine.