Treatment Outcomes after Postoperative Radiotherapy in Triple-Negative Breast Cancer: Multi-Institutional Retrospective Study (KROG 17-05)

Jin Hee Kim ¹, Sang Jun Byun ¹, Myeongsoo Kim ¹

⁰Department of Radiation Oncology, Dongsan Hospital, Keimyung University School of Medicine, 1035 Dalgubeol-daero Dalseo-gu, Daegu 42601, Republic of Korea.

Journal of Personalized Medicine +

|

September 28, 2024

View abstract on PubMed

Summary

Postoperative radiotherapy for triple-negative breast cancer (TNBC) in South Korea showed high survival rates. T and N stages, lympho-vascular invasion, and Ki-67 expression are key prognostic factors for patient outcomes.

Area Of Science

Oncology
Radiotherapy
Breast Cancer Research

Background

Triple-negative breast cancer (TNBC) presents unique challenges in treatment and prognosis.
Postoperative radiotherapy (PORT) is a critical component of TNBC management.
Understanding failure patterns and prognostic factors after PORT is essential for improving patient outcomes.

Purpose Of The Study

To investigate failure patterns, survival rates, and prognostic factors in South Korean TNBC patients receiving PORT.
To identify key clinical and biological factors influencing outcomes after PORT for TNBC.

Main Methods

A multi-institutional retrospective study involving 699 TNBC patients who underwent PORT.
Data collected from six institutions between 2008 and 2010, with a median follow-up of 94 months.
Analysis included overall survival, loco-regional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS), and disease-free survival (DFS).

Main Results

Patients achieving pathologic complete remission after neoadjuvant chemotherapy showed no treatment failure.
Distant metastasis was the primary cause of treatment failure.
Five-year survival rates: overall (91.4%), LRRFS (92.3%), DMFS (89.4%), and DFS (85.2%).
T and N stages, lympho-vascular invasion (LVI), and Ki-67 expression were significant prognostic factors.

Conclusions

T and N stages, LVI, and Ki-67 expression are significantly associated with survival outcomes in TNBC patients post-PORT.
These factors can aid in risk stratification and personalized treatment strategies for TNBC.

Keywords:

failure pattern prognostic factors radiotherapy survival triple-negative breast neoplasms

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