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Biomarkers and Rehabilitation for Functional Neurological Disorder.

Victor W Mark^1,2,3

¹Department of Physical Medicine and Rehabilitation, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Journal of Personalized Medicine

|September 28, 2024

Summary

Functional neurological disorder (FND) has biological markers and is a neurological condition, not just a mental illness. Research highlights shared biomarkers with other neurological disorders and effective physical rehabilitation outcomes.

Keywords:

MRI functional neurological disorder rehabilitation

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Area of Science:

Neurology
Neuroscience
Psychiatry

Background:

Functional neurological disorder (FND) is often misunderstood as purely psychological.
This misconception stems from its intermittent symptoms and historical views, leading to patient stigma and social isolation.

Purpose of the Study:

To review current research on FND biomarkers.
To examine the overlap of FND biomarkers with those of canonical neurological disorders.
To highlight the efficacy of physical rehabilitation for FND.

Main Methods:

Literature review of FND biomarker research.
Analysis of shared features between FND and established neurological disorders.
Evaluation of outcomes from physical rehabilitation trials in FND patients.

Main Results:

FND exhibits numerous biological markers beyond psychiatric associations.
Significant overlap exists between FND biomarkers and those found in canonical neurological disorders.
Physical rehabilitation trials show encouraging outcomes for FND patients.

Conclusions:

FND is a neurological disorder with widespread biological abnormalities.
Understanding FND's biological basis can improve patient care and reduce stigma.
Further research and improved healthcare provider education are crucial for FND management.