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Assessing the Utility of Prediction Scores PAINT, ISARIC4C, CHIS, and COVID-GRAM at Admission and Seven Days after Symptom Onset for COVID-19 Mortality

  • 0Department of Professional Legislation in Dental Medicine, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Journal of Personalized Medicine +

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September 28, 2024

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September 28, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Four COVID-19 prediction scores accurately predict mortality in hospitalized patients. These scores, including PAINT, ISARIC4C, CHIS, and COVID-GRAM, become more effective seven days post-symptom onset.

Area Of Science

  • Infectious Diseases
  • Epidemiology
  • Clinical Medicine

Background

  • The COVID-19 pandemic necessitates reliable prognostic tools for patient outcome prediction.
  • Accurate assessment of hospitalized COVID-19 patients is crucial for timely intervention.

Purpose Of The Study

  • To evaluate the predictive performance of four prominent COVID-19 prediction scores: PAINT, ISARIC4C, CHIS, and COVID-GRAM.
  • To assess the utility of these scores in predicting mortality at admission and seven days post-symptom onset.

Main Methods

  • Retrospective analysis of 215 adult patients hospitalized with confirmed SARS-CoV-2 infection.
  • Evaluation of PAINT, ISARIC4C, CHIS, and COVID-GRAM scores at admission and seven days post-symptom onset.
  • Statistical analysis using ROC curves and logistic regression to determine predictive accuracy for mortality.

Main Results

  • All four scores significantly differentiated between survivors and non-survivors at admission (p < 0.0001).
  • Optimal cutoff values at admission demonstrated high sensitivity and specificity for predicting mortality.
  • Predictive accuracy and hazard ratios increased by day seven post-symptom onset, indicating enhanced prognostic value over time.

Conclusions

  • The evaluated COVID-19 prediction scores are robust tools for predicting mortality in hospitalized patients.
  • These scores demonstrate increased prognostic significance seven days after symptom onset.
  • Clinical implementation of these scores can aid in early identification and intervention for high-risk COVID-19 patients.

Keywords:

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