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The Cardioprotective Potential of Herbal Formulas in Myocardial Infarction-Induced Heart Failure through Inhibition

Youn-Jae Jang1,2, Hye-Yoom Kim1, Se-Won Na1,2

  • 1Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, Iksan 54538, Republic of Korea.

Pharmaceuticals (Basel, Switzerland)
|September 28, 2024
PubMed

Insights

Dohongsamul-tang (DHT) significantly improved cardiac function and reduced heart damage in a rat model of myocardial infarction (MI)-induced heart failure. This traditional Korean herbal formula shows potential for treating heart failure by modulating key molecular pathways.

Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Traditional Medicine

Background:

  • Myocardial infarction (MI) is a primary cause of heart failure, leading to detrimental cardiac remodeling.
  • Existing treatments for MI-induced heart failure often have limitations, necessitating novel therapeutic strategies.
  • Traditional herbal medicines represent a potential source for new cardioprotective agents.

Purpose of the Study:

  • To investigate the cardioprotective effects of Dohongsamul-tang (DHT), a traditional Korean herbal formula, in a rat model of MI-induced heart failure.
  • To evaluate the impact of DHT on cardiac function, infarct size, cardiac biomarkers, and molecular signaling pathways.

Main Methods:

  • Myocardial infarction was induced in rats via left anterior descending (LAD) artery ligation.
  • Rats were treated with two doses of DHT (100 mg/kg or 200 mg/kg) daily for 8 weeks.
  • Cardiac function (ejection fraction, fractional shortening), infarct size, heart weight, biomarker levels (LDH, CK-MB), left ventricle fibrosis, and molecular markers (phospho-JAK, phospho-STAT3, Bax/Bcl-2, caspase-3) were assessed.

Main Results:

  • DHT treatment significantly improved ejection fraction and fractional shortening, indicating enhanced cardiac function.
  • DHT markedly reduced infarct size, heart weight, and levels of heart failure biomarkers (LDH, CK-MB).
  • DHT treatment decreased left ventricle fibrosis and inhibited pro-apoptotic and inflammatory signaling pathways, including JAK/STAT3.

Conclusions:

  • Dohongsamul-tang (DHT) demonstrates significant cardioprotective effects against MI-induced heart failure in a rat model.
  • DHT improves cardiac function, reduces cardiac damage, and mitigates adverse cardiac remodeling.
  • The cardioprotective mechanisms of DHT involve the modulation of the JAK/STAT3 signaling pathway, suggesting its potential as a therapeutic agent for heart failure.

Keywords:
cardiac functioncardioprotectiondohongsamul-tangheart failurekorean herbal formulasmyocardial infarction

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