From the "One-Molecule, One-Target, One-Disease" Concept towards Looking for Multi-Target Therapeutics for Treating...

Area of Science:

• Virology
• Infectious Diseases
• Drug Discovery

Background:

• Non-polio enteroviruses (NPEVs) cause diverse illnesses, some leading to severe conditions in vulnerable populations.
• Current treatments for NPEV infections are lacking, with clinical trials of antiviral drugs yielding unsuccessful results.

Purpose of the Study:

• To explore the potential of the multi-target directed ligand (MTDL) strategy for developing effective treatments against NPEVs.
• To analyze registered clinical trials to identify promising antiviral drug candidates for MTDL synthesis.

Main Methods:

• Systematic analysis of registered clinical trials for antiviral drugs targeting enteroviruses.
• Development of filters for selecting lead compounds suitable for MTDL synthesis.
• Evaluation of virus and compound data to assess MTDL potential.

Main Results:

• The study highlights the potential of MTDL strategy to overcome limitations of current antiviral approaches.
• Identified strategies to broaden antiviral spectrum, enhance potency, and reduce adverse effects.
• Discussed data on viral characteristics and lead compounds for MTDL development.

Conclusions:

• The MTDL strategy presents a novel perspective for improving enterovirus treatment efficacy and reducing drug resistance.
• This approach could lead to more cost-effective drug design and broader antiviral activity.
• Further research into MTDL synthesis and application is warranted for enterovirus infections.