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Gut Microbiota in Patients Receiving Dialysis: A Review
Xintian Lim1, Lijin Ooi1, Uzhe Ding1
1Department of Renal Medicine, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.
Pathogens (Basel, Switzerland)
|September 28, 2024
Summary
The gut microbiota is altered in patients with kidney disease, especially those on dialysis. Understanding these changes may lead to new treatments to improve patient outcomes.
Area of Science:
- Microbiology
- Nephrology
- Gastroenterology
Background:
- The human gut microbiota plays a vital role in health and disease.
- Chronic kidney disease (CKD) and end-stage kidney disease (ESKD) are linked to gut dysbiosis.
- Dysbiosis is associated with adverse outcomes in ESKD patients, particularly those on dialysis.
Purpose of the Study:
- To review the current evidence on gut microbiota alterations in dialysis patients.
- To highlight the importance of gut microbial balance for kidney health and patient outcomes.
- To explore potential therapeutic targets for improving outcomes in dialysis patients.
Main Methods:
- Literature review of studies focusing on gut microbiota in dialysis patients.
- Analysis of factors contributing to gut dysbiosis in CKD and ESKD.
- Evaluation of potential therapeutic interventions for gut microbiota modulation.
Main Results:
- Gut microbiota dysregulation is a significant factor in CKD and ESKD.
- Factors like uremic toxins, inflammation, and diet influence dysbiosis in dialysis patients.
- Specific microbial signatures may offer targets for personalized treatments.
Conclusions:
- Gut microbiota alterations are prevalent and impactful in dialysis patients.
- Further research is needed to validate therapeutic strategies for gut microbiota modulation in this population.
- Optimizing gut microbial balance holds promise for improving outcomes in individuals undergoing dialysis.
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