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Collagen and Its Derivatives Serving Biomedical Purposes: A Review
Hanna Wosicka-Frąckowiak1, Kornelia Poniedziałek1, Stanisław Woźny1
1GENERICA Pharmaceutical Lab, Regionalne Centrum Zdrowia Sp. z o.o., ul. Na Kępie 3, 64-360 Zbąszyń, Poland.
Polymers
|September 28, 2024
Summary
Collagen biomaterials offer excellent biocompatibility for medical applications. This review explores collagen sources, processing, and applications in tissue engineering and drug delivery, highlighting future trends.
Area of Science:
- Biomaterials Science
- Biomedical Engineering
- Materials Science
Background:
- Collagen is a key biomaterial with high biocompatibility, biodegradability, and low toxicity.
- Its native structure is vital for preserving beneficial characteristics.
- Chemical modifications present challenges for tailored clinical applications.
Purpose of the Study:
- To comprehensively review collagen biomaterials, including sources, extraction, processing, and properties.
- To discuss challenges in chemical modification for specific clinical needs.
- To explore current and future trends in collagen-based biomaterials.
Main Methods:
- Literature review of collagen biomaterials.
- Analysis of extraction, processing, and modification techniques.
- Examination of various collagen-based material forms and applications.
Main Results:
- Collagen and its derivatives are valuable biomaterials due to inherent biocompatibility and biodegradability.
- Various forms of collagen-based materials (solutions, hydrogels, scaffolds, etc.) are suitable for diverse applications.
- Preserving native collagen structure is critical; chemical modifications require careful consideration.
Conclusions:
- Collagen-based biomaterials are versatile for regenerative medicine, tissue engineering, drug delivery, and wound healing.
- Future research directions include collagen bioinks for 3D bioprinting and advanced nanoparticle drug delivery systems.
- Continued exploration of collagen derivatives will drive innovation in medical and pharmaceutical fields.
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