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Lipid-Based Nanocarriers: Bridging Diagnosis and Cancer Therapy
Alessandra Giordano1, Anna Chiara Provenza1, Giorgio Reverchon2
1Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
Pharmaceutics
|September 28, 2024
Summary
Lipid-based nanocarriers offer a powerful platform for cancer theranostics, integrating diagnostics and therapeutics for personalized medicine. This review explores their potential, challenges, and the need for collaboration to advance their clinical use.
Area of Science:
- Nanomedicine
- Biotechnology
- Oncology
Background:
- Theranostics combines diagnostic and therapeutic functions for synergistic or sequential treatment.
- Lipid-based nanocarriers are investigated for their biocompatibility, biodegradability, and targeting abilities in theranostics.
- Precision medicine aims to tailor treatments using real-time diagnostic information.
Purpose of the Study:
- To review recent advances in lipid-based nanocarriers for cancer theranostics.
- To explore strategies for enhancing in vivo performance of these nanocarriers.
- To identify and discuss challenges and barriers to clinical translation.
Main Methods:
- Literature review of current research on lipid-based nanocarriers in cancer theranostics.
- Analysis of strategies for improving in vivo performance.
- Examination of challenges such as regulatory hurdles, cost, and technological integration.
Main Results:
- Lipid-based nanocarriers show significant potential for improving cancer theranostics and precision medicine.
- Various approaches exist to enhance their in vivo performance and therapeutic efficacy.
- Key challenges include regulatory issues, high costs, and the need for technological integration.
Conclusions:
- Lipid-based nanocarriers hold promise for personalized medicine, reducing side effects and improving patient outcomes.
- Multidisciplinary collaboration is essential to overcome barriers and facilitate clinical translation.
- Addressing these challenges will unlock the full potential of nanomedicine in theranostics.

