Exploring Protein-Based Carriers in Drug Delivery: A Review

Area of Science:

• Biomaterials Science
• Nanotechnology
• Pharmaceutical Sciences

Background:

• Drug delivery systems (DDSs) are critical for developing new treatments, addressing challenges in drug transport and pharmacokinetics.
• Nanotechnology-based DDSs, including nanoparticles and micelles, offer targeted delivery and sustained release.
• Protein-based DDSs are emerging as a promising alternative to synthetic polymers due to their biocompatibility and biodegradability.

Purpose of the Study:

• To provide a comprehensive overview of protein-based drug delivery systems.
• To highlight current trends, challenges, and future perspectives in this field.
• To focus on protein types and enhancement techniques for drug affinity and targeting.

Main Methods:

• Review of current literature on protein-based drug delivery systems.
• Analysis of various protein sources (gelatin, albumin, collagen, gliadin, silk proteins).
• Examination of techniques to improve drug loading, targeting, and release profiles.

Main Results:

• Protein-based carriers exhibit excellent stability under physiological conditions.
• These systems facilitate controlled and sustained drug release, enhancing therapeutic efficacy.
• Various proteins demonstrate potential for revolutionizing targeted and efficient drug delivery.

Conclusions:

• Protein-based DDSs present significant advantages, including safety, biocompatibility, and biodegradability.
• They offer a viable and effective strategy for optimizing drug delivery and therapeutic outcomes.
• Further research into protein modification and functionalization will enhance their therapeutic impact.