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  11. Pelargonium Graveolens: Towards In-depth Metabolite Profiling, Antioxidant And Enzyme-inhibitory Potential

Pelargonium graveolens: Towards In-Depth Metabolite Profiling, Antioxidant and Enzyme-Inhibitory Potential

Reneta Gevrenova1, Gokhan Zengin2, Vessela Balabanova1

  • 1Department of Pharmacognosy, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.

Plants (Basel, Switzerland)
|September 28, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

This study reveals that rose geranium leaf extract is rich in phytochemicals, demonstrating significant antioxidant and enzyme inhibitory properties. These findings highlight its potential for pharmaceutical and nutraceutical applications.

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Natural Products

Background:

  • Pelargonium graveolens L'Hèr. (Geraniaceae) is traditionally recognized for its flavor, ornamental, and medicinal uses.
  • Comprehensive phytochemical profiling and in vitro bioactivity assessment of P. graveolens leaf extract are needed.

Purpose of the Study:

  • To conduct an in-depth phytochemical analysis of P. graveolens leaf extract.
  • To evaluate the in vitro antioxidant capacity and enzyme inhibition potential of the extract.

Main Methods:

  • Phytochemical profiling was performed using Ultra-High-Performance Liquid Chromatography coupled with High-Resolution Mass Spectrometry (UHPLC-HRMS).
  • In vitro antioxidant assays included DPPH, ABTS, CUPRAC, FRAP, and phosphomolybdenum assays.
  • Enzyme inhibition was assessed against acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-glucosidase, α-amylase, and lipase.
Keywords:
Pelargonium graveolensantioxidantsenzyme inhibitionphenolics

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Main Results:

  • UHPLC-HRMS identified over 110 secondary metabolites, including novel acylcitric, feruloyltartaric, and coumaroyltartaric acids in the species.
  • The extract exhibited potent radical scavenging activity (DPPH, ABTS), high reducing power (CUPRAC, FRAP), and metal chelating capacity.
  • Significant inhibition was observed against acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-glucosidase, α-amylase, and lipase.

Conclusions:

  • The phytochemical profile of P. graveolens leaf extract is rich and diverse, featuring numerous bioactive compounds.
  • The extract demonstrates substantial antioxidant and enzyme inhibitory activities, supporting its traditional medicinal uses.
  • These findings suggest promising applications for rose geranium extract in the pharmaceutical and nutraceutical industries.