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Updated: Jun 11, 2025

Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System
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Hepatitis B Viral Protein HBx: Roles in Viral Replication and Hepatocarcinogenesis

Dong Li1, Yassir Hamadalnil2, Thomas Tu1,3

  • 1The Westmead Institute for Medical Research, Faculty of Medicine, The University of Sydney, Westmead, NSW 2145, Australia.

Viruses
|September 28, 2024
PubMed
Summary

Hepatitis B virus X protein (HBx) drives viral replication and liver cancer. This review covers HBx functions, therapeutic targets, and its role in hepatocarcinogenesis, identifying key research gaps.

Keywords:
DBB1HBV DNA integrationHCCcancer evolutioncccDNAhepadnavirushepatocellular carcinomatranscriptional regulation

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