Central and Peripheral Nervous System Manifestations Associated with Dengue Illness

Area of Science:

• * Arbovirology and infectious disease epidemiology.
• * Global public health and tropical medicine.

Background:

• * Dengue virus (DENV) infections pose a significant global health challenge with rising incidence.
• * Increasingly recognized severe manifestations include neurological complications, alongside traditional hemorrhagic fever.
• * Factors like vector expansion and climate change are driving intensified dengue transmission.

Purpose of the Study:

• * To provide an overview of current dengue epidemiology, clinical spectrum, and neurological involvement.
• * To highlight critical research priorities for dengue control and management.
• * To emphasize the need for integrated approaches to mitigate the global burden of dengue.

Main Methods:

• * Review of current scientific literature on dengue epidemiology, clinical features, and diagnostics.
• * Analysis of diagnostic methods including RT/PCR, NS1 antigen detection, and serological assays.
• * Identification of research gaps and priorities based on existing knowledge.

Main Results:

• * Dengue's clinical spectrum ranges from mild fever to severe neurological conditions like encephalitis and myelitis.
• * Neurological manifestations, though once rare, are now frequently reported.
• * Current diagnostic tools are established, but gaps remain in treatment and prevention.

Conclusions:

• * Effective dengue control requires addressing research priorities in vaccines, antivirals, surveillance, and predictive modeling.
• * Long-term studies on post-dengue sequelae are crucial for comprehensive patient care.
• * Integrated and holistic public health programs are essential to combat the escalating global impact of dengue.