Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Possible non-involvement of lipoxygenase pathway in the cerebral blood flow decrease due to indomethacin.

N el Bouchi, A Fradin, C Capdeville

    European Journal of Pharmacology
    |August 27, 1985
    PubMed
    Summary

    Indomethacin significantly reduced cerebral blood flow (CBF) in rats by decreasing prostaglandins. Vasoconstrictory leukotrienes were not involved in this indomethacin-induced CBF reduction.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Contrasted resistance and resilience of two mangrove forests after exposure to long-term and short-term anthropic disturbances.

    Marine environmental research·2019
    Same author

    Spontaneous resurgence of conditioned fear weeks after successful extinction in brain injured mice.

    Progress in neuro-psychopharmacology & biological psychiatry·2018
    Same author

    Limited impact of several years of pretreated wastewater discharge on fauna and vegetation in a mangrove ecosystem.

    Marine pollution bulletin·2018
    Same author

    Detection of vascular cell adhesion molecule-1 expression with USPIO-enhanced molecular MRI in a mouse model of cerebral ischemia.

    Contrast media & molecular imaging·2013
    Same author

    Diffraction techniques and vibrational spectroscopy opportunities to characterise bones.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2009
    Same author

    Plasma concentrations of arginine and related amino acids following traumatic brain injury: Proline as a promising biomarker of brain damage severity.

    Nitric oxide : biology and chemistry·2007

    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Indomethacin is known to affect prostaglandin synthesis.
    • Cerebral blood flow (CBF) regulation is complex and involves various signaling molecules.

    Purpose of the Study:

    • To investigate the role of prostaglandins and leukotrienes in indomethacin-induced reduction of local cerebral blood flow (l.CBF) in rats.

    Main Methods:

    • Local cerebral blood flow (l.CBF) was measured in the frontal cortex of unanesthetized rats using the hydrogen clearance technique.
    • Levels of prostaglandins (PGD2, PGE2, PGF2 alpha) and 6-keto-PGF1 alpha were quantified.
    • The effects of lipoxygenase inhibitors (BW 755C, nordihydroguaiaretic acid) and a leukotriene receptor antagonist (FPL 55712) were assessed.

    Main Results:

    Related Experiment Videos

  • Indomethacin (10 mg/kg i.p.) caused a significant decrease in l.CBF.
  • Brain prostaglandin levels (PGD2, PGE2, PGF2 alpha) and 6-keto-PGF1 alpha were significantly reduced by indomethacin.
  • Inhibitors of lipoxygenase and the leukotriene receptor antagonist did not alter the indomethacin-induced decrease in l.CBF.

    • Conclusions:

    • Indomethacin-induced reduction in cerebral blood flow is associated with decreased prostaglandin levels.
    • The involvement of vasoconstrictory leukotrienes in indomethacin's effect on l.CBF appears minimal.