Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Action Potentials01:41

Action Potentials

142.8K
Overview
142.8K
Action Potential01:31

Action Potential

4.7K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
4.7K
Action Potential01:14

Action Potential

11.4K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
11.4K
Fixed Action Patterns01:06

Fixed Action Patterns

17.7K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.7K
Antibody Actions01:26

Antibody Actions

2.8K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
2.8K
Principles of Drug Action01:24

Principles of Drug Action

8.7K
Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Application of specific ELISAs for BMP15 and GDF9 to cumulus cell extracts from infertile women.

Molecular and cellular endocrinology·2023
Same author

Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder.

Translational psychiatry·2017
Same author

Zika Virus RNA in an Asymptomatic Donor's Vitreous: Risk of Transmission?

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development.

Journal of assisted reproduction and genetics·2014
Same author

A particulate isotopic standard of plutonium in an aluminosilicate matrix.

Journal of the American Society for Mass Spectrometry·2013
Same author

Biological activity and metabolic clearance of recombinant human follicle stimulating hormone produced in Sp2/0 myeloma cells.

Cytotechnology·2012

Related Experiment Video

Updated: Feb 8, 2026

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)
09:38

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Published on: September 5, 2025

914

Inhibin: 1985 update on action and purification.

F H de Jong, D M Robertson

    Molecular and Cellular Endocrinology
    |September 1, 1985
    PubMed
    Summary

    Inhibin, a hormone regulating FSH secretion, has been challenging to isolate. Recent research identifies two distinct inhibin forms: a larger gonadal protein and a smaller seminal protein, with only the gonadal form likely involved in FSH regulation.

    Area of Science:

    • Endocrinology
    • Reproductive Biology
    • Hormone Research

    Background:

    • Inhibin, a gonadal hormone, regulates pituitary follitropin (FSH) secretion.
    • Despite being postulated over 60 years ago, inhibin's isolation and characterization faced significant challenges.
    • Previous difficulties stemmed from ill-defined assays, varied sources, and purification issues.

    Purpose of the Study:

    • To review and contextualize recent advancements in inhibin isolation and characterization.
    • To clarify the nature and biological relevance of different inhibin forms.
    • To assess the role of identified inhibin forms in FSH regulation.

    Main Methods:

    • Literature review of recent publications on inhibin isolation and characterization.
    • Analysis of molecular mass and source of inhibin-like proteins.

    More Related Videos

    The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
    06:05

    The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

    Published on: February 19, 2021

    1.8K
    Corticospinal Excitability Modulation During Action Observation
    12:33

    Corticospinal Excitability Modulation During Action Observation

    Published on: December 31, 2013

    9.4K

    Related Experiment Videos

    Last Updated: Feb 8, 2026

    Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)
    09:38

    Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

    Published on: September 5, 2025

    914
    The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
    06:05

    The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

    Published on: February 19, 2021

    1.8K
    Corticospinal Excitability Modulation During Action Observation
    12:33

    Corticospinal Excitability Modulation During Action Observation

    Published on: December 31, 2013

    9.4K
  • Evaluation of in vitro assay data for purified inhibin preparations.

    • Main Results:

    • At least two classes of proteins with inhibin-like activity have been identified.
    • A larger form (40-70 kDa) is found in gonadal extracts and fluids.
    • A smaller form (5-20 kDa) found in seminal plasma is likely prostatic and not involved in gonadal FSH regulation.

    Conclusions:

    • The larger gonadal inhibin form is the primary candidate for regulating FSH secretion.
    • The role of purified gonadal inhibin preparations in vivo requires further establishment.
    • Seminal plasma inhibin is unlikely to be involved in the gonadal regulation of FSH.