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Cancer Development and Progression in Patients with Heart Failure
Katharina Seuthe1, Felix Simon Ruben Picard2,3, Holger Winkels2,3
1Department of Cardiology, Clinic III for Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Strasse 62, 50937, Cologne, Germany. katharina.seuthe@uk-koeln.de.
Current Heart Failure Reports
|September 28, 2024
Summary
Heart failure (HF) patients show increased cancer risk and mortality. Emerging research suggests HF may be an independent risk factor for cancer, necessitating screening and targeted interventions.
Area of Science:
- Cardiology
- Oncology
- Translational Medicine
Background:
- The co-occurrence of heart failure (HF) and cancer presents a significant clinical challenge.
- Patients with cardiovascular disease (CVD), especially HF, have a higher risk of developing cancer.
- The complex interplay between HF and cancer warrants further investigation.
Purpose of the Study:
- To review the current understanding of cancer development in HF patients.
- To explore potential mechanisms, risk factors, and clinical implications of this association.
- To highlight emerging research on the link between HF and cancer.
Main Methods:
- Literature review of epidemiological and preclinical data.
- Analysis of existing cardiovascular trials and molecular mechanisms.
- Synthesis of evidence on cancer incidence, mortality, and progression in HF patients.
Main Results:
- HF patients exhibit higher cancer incidence and mortality, particularly those with HF with preserved ejection fraction.
- Preclinical data identifies novel pathways, such as SerpinA3, potentially linking HF to cancer progression.
- HF is suggested as an independent risk factor for cancer development.
Conclusions:
- Preliminary evidence supports cancer development in HF patients, indicating a need for clinical interventions.
- Recommended interventions include cancer screening in HF patients and preventative strategies for both conditions.
- Further research is needed to elucidate the molecular and cellular cross-talk between HF and cancer.
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