Computational model of layer 2/3 in mouse primary visual cortex explains observed visuomotor mismatch response

Activity in layer 2/3 of the mouse primary visual cortex has been shown to depend both on visual input and the mouse's locomotion. Moreover, this activity is altered by a mismatch between the observed visual flow and the predicted visual flow from locomotion. Here, I present a simple computational model that explains previously reported recordings from layer 2/3 neurons in mice. In my model, layer 2/3 encodes the velocity difference between the estimate from visual flow and the prediction from locomotion using a neural population code. Moreover, I describe a hypothesized mechanism for how the brain may carry out computations of variables encoded in population codes. This mechanism may point to a general principle for computing any mathematical function in the brain.