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Case report: Supraglottic SCC with sphenoid and cavernous sinus metastases
N A O'Keeffe1, E Chiriac2, A Dias1
1Department of Otolaryngology/Head & Neck Surgery, South Infirmary-Victoria University Hospital, Cork, Ireland.
International Journal of Surgery Case Reports
|September 28, 2024
Summary
This case report details a rare instance of sinonasal metastases originating from glottic squamous cell carcinoma (SCC). It highlights an unusual metastatic pathway for laryngeal cancer.
Area of Science:
- Otolaryngology
- Oncology
- Head and Neck Surgery
Background:
- Sinonasal metastases are uncommon, with primary sites typically being the kidneys, lungs, breast, thyroid, and prostate.
- Metastases from laryngeal cancer to the sinonasal region are exceptionally rare.
Observation:
- A 75-year-old patient with a history of glottic squamous cell carcinoma (SCC) presented with neck swelling and hoarseness.
- The patient later developed cranial nerve involvement, raising suspicion for sinonasal metastases.
Findings:
- This report describes a unique case of sphenoid and cavernous sinus metastases in a patient with glottic cancer.
- To the authors' knowledge, this is the first reported case of supraglottic metastases to the sphenoid and cavernous sinus.
Implications:
- This case expands the understanding of metastatic spread patterns in head and neck malignancies.
- Recognizing this rare metastatic pathway is crucial as it can be associated with a poor prognosis.

