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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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Preparation and release pattern study of long-term controlled release Blonanserin microspheres
Xiangqin Chen1, Shengnan Qiu1, Yanbin Shi2
1Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medience, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong Province, 250012, China.
International Journal of Pharmaceutics
|September 28, 2024
Summary
This study developed Blonanserin microspheres using mixed molecular weight PLGA, achieving a near-zero release model without a lag phase. The optimized formulation ensures sustained antipsychotic delivery for up to 35 days.
Area of Science:
- Biomaterials Science
- Pharmaceutics
- Drug Delivery Systems
Background:
- Poly(lactic-co-glycolic) acid (PLGA) microspheres are widely used for sustained drug delivery.
- Achieving controlled release without an initial burst or lag phase remains a challenge.
- Blonanserin is an antipsychotic requiring optimized delivery for therapeutic efficacy.
Purpose of the Study:
- To prepare Blonanserin-loaded PLGA microspheres (Bn-MS) with a near-zero release profile and no initial release lag.
- To investigate the effect of mixing different molecular weights of PLGA on microsphere release kinetics.
- To achieve long-term, stable drug release for improved antipsychotic therapy.
Main Methods:
- Preparation of Blonanserin microspheres using microfluidics with varying ratios of 15 kDa and 75 kDa PLGA.
- Monitoring particle size and morphology changes during in vitro release.
- Fitting release kinetic models to understand the release pattern and mechanism.
Main Results:
- Mixing PLGA of different molecular weights successfully eliminated the release hysteresis period.
- The optimal ratio (1:9 of 15 kDa:75 kDa PLGA) resulted in low burst release, moderate release rate, and no lag phase.
- Microspheres exhibited a stable, near-zero release pattern for up to 35 days.
Conclusions:
- Hybrid PLGA microspheres effectively control Blonanserin release kinetics.
- Adjusting PLGA molecular weight ratios is a viable strategy for eliminating release lag and achieving sustained drug delivery.
- This approach offers a promising method for long-term antipsychotic treatment with improved patient compliance.
