Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Ultrasound-Mediated Treatments on Dental Biofilm Attachment and Viability.

Ultrasound in medicine & biology·2026
Same author

3D bone printing via ultrasound-mediated osteogenic differentiation of stem cells (3DBonUS).

Biofabrication·2026
Same author

Perfluorocarbon nanodroplets are cytocompatible with osteoblast-lineage cells and modulate in vitro osteoclastogenesis differentially in normoxia and hypoxia.

Scientific reports·2026
Same author

Microbubbles manufactured using a tissue homogeniser: DoE-guided optimisation for a narrower size distribution and higher yield.

International journal of pharmaceutics·2026
Same author

Wound healing and photodynamic potential of <i>Adiantum capillus-veneris</i> L. (Pteridaceae): an evaluation of the cellular effects and molecular insights.

Frontiers in pharmacology·2026
Same author

The interplay between bacterial biofilms, encrustation, and wall shear stress in ureteral stents: a review across scales.

Frontiers in urology·2025
Same journal

Artificial intelligence and CRISPR-based approaches for targeted delivery of bacteriophages.

International journal of pharmaceutics·2026
Same journal

A "three-in-one" nose-to-brain delivery strategy: intranasal vancomycin spray achieves simultaneous clearance of pneumococcal colonization, bacteremia, and meningitis.

International journal of pharmaceutics·2026
Same journal

10-Hydroxy-2-decenoic acid /matrine deep eutectic solvent encapsulated in hyalurosomes for enhanced transdermal delivery and antioxidant efficacy.

International journal of pharmaceutics·2026
Same journal

Dual-trigger hyaluronic acid nanoprodrug incorporating a 2-nitrobenzenesulfonyl linker for CD44-targeted and glutathione-responsive drug delivery.

International journal of pharmaceutics·2026
Same journal

Polymeric mixed micellar nanogel enhances dermal delivery and therapeutic efficacy of tofacitinib citrate.

International journal of pharmaceutics·2026
Same journal

Localized gold nanoparticles-mediated photothermal therapy for head and neck cancer: in vivo proof-of-concept.

International journal of pharmaceutics·2026
See all related articles

Related Experiment Video

Updated: Jun 11, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

3.8K

Ultrasound-compatible 3D-printed Franz diffusion system for sonophoresis with microbubbles.

Xin Chen1, Davide De Grandi2, Yonglian Zhu1

  • 1School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.

International Journal of Pharmaceutics
|September 28, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a novel 3D-printed Franz diffusion cell for sonophoresis, enhancing topical drug delivery with ultrasound and microbubbles. The new system significantly boosts drug permeation through skin membranes.

Keywords:
3D printingIn-vitro diffusion systemMicrobubblesSonophoresisUltrasound

More Related Videos

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells
07:16

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Published on: January 21, 2021

3.0K
Studying Cavitation Enhanced Therapy
07:36

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

5.2K

Related Experiment Videos

Last Updated: Jun 11, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

3.8K
Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells
07:16

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Published on: January 21, 2021

3.0K
Studying Cavitation Enhanced Therapy
07:36

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

5.2K

Area of Science:

  • Pharmacology
  • Biomaterials Engineering
  • Acoustic Engineering

Background:

  • Sonophoresis utilizes ultrasound to improve topical drug delivery, but research on ultrasound-responsive carriers like microbubbles is limited.
  • Existing Franz diffusion cells are not compatible with ultrasound, hindering studies on sonophoresis.
  • Characterization of acoustical behavior in traditional systems is insufficient for advanced applications.

Purpose of the Study:

  • To design and characterize a novel Franz diffusion cell compatible with ultrasound for sonophoresis.
  • To evaluate the efficacy of ultrasound-responsive drug carriers (imiquimod-loaded microbubbles) in enhancing topical drug delivery.
  • To assess the performance of a 3D-printed donor compartment for sonophoresis applications.

Main Methods:

  • Fabrication of a 3D-printed Franz cell donor compartment using photoreactive resin, designed for ultrasound integration.
  • Functional characterization of the novel assembly for liquid retention, drug absorption, and ultrasound field predictability.
  • Application of the developed assembly in sonophoresis experiments using imiquimod-loaded microbubbles and StratM® membrane.

Main Results:

  • The 3D-printed assembly demonstrated effective liquid retention and comparable imiquimod absorption to glass.
  • A predictable ultrasound field was generated without significant spatial distortion.
  • Sonophoresis with microbubbles significantly enhanced imiquimod permeation (2.96 ± 0.25 μg) and partitioning (3.84 ± 0.39 μg) compared to passive diffusion (1.74 ± 0.29 μg and 2.29 ± 0.32 μg) over 24 hours.

Conclusions:

  • A novel, 3D-printed Franz diffusion cell assembly is suitable for sonophoresis research.
  • The developed system enables effective characterization of ultrasound-responsive drug delivery systems.
  • This technology significantly enhances topical drug permeation, showing promise for advanced drug delivery applications.