Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

2.7K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
2.7K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

482
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
482
Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

2.2K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
2.2K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
Regulation of Heart Rates01:31

Regulation of Heart Rates

1.7K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
1.7K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

582
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
582

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heart Failure Wired from Shock to Devices and Home: A New Era of Delivery.

US cardiology·2026
Same author

Efficacy and safety of Tirzepatide in patients with heart failure with preserved ejection fraction: A systematic review and meta-analysis.

Disease-a-month : DM·2026
Same author

Frontline aspiration versus stent retriever thrombectomy for M2 occlusions: Insights from the STAR registry.

European stroke journal·2026
Same author

Revascularization for Ischemic Cardiomyopathy: Disproving the 45-Year-Old Concept of Hibernating Myocardium.

Annual review of medicine·2026
Same author

Outcomes After Intracranial Rescue Stenting for Acute Ischemic Stroke.

Stroke (Hoboken, N.J.)·2026
Same author

Endovascular Thrombectomy With and Without Preceding Thrombolysis in Posterior Circulation Stroke-Insights From STAR.

Stroke (Hoboken, N.J.)·2026
Same journal

Predictors and Outcomes of Heart Failure Diagnosis in the Community When Compared to Acute Care Settings: Insights from Linked Administrative Health Databases.

Journal of cardiac failure·2026
Same journal

Digitalis Today: From Doctrine to Disrepute to Disciplined Reconsideration.

Journal of cardiac failure·2026
Same journal

What Are HFpEF Mimics and What Are They Mimicking? Insights Into Our Conceptualization of Heart Failure With Preserved Ejection Fraction as a Disease.

Journal of cardiac failure·2026
Same journal

Right Ventricular Function and Echocardiographic Characteristics After Left Atrial to Coronary Sinus Shunting; Insights from ALT-FLOW Early Feasibility Study 3 Year Follow-Up.

Journal of cardiac failure·2026
Same journal

Greater Splanchnic Nerve Ablation Produces Echocardiographic Evidence of Reduced Left Ventricular Filling Pressures Across 12 Months of Follow-Up.

Journal of cardiac failure·2026
Same journal

JCF In Case You Missed It! Summary of American College of Cardiology (ACC) 2026.

Journal of cardiac failure·2026
See all related articles

Related Experiment Video

Updated: Jun 11, 2025

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
09:56

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

4.9K

Baroreflex Function in Cardiovascular Disease.

Husam M Salah1, Richa Gupta2, Albert J Hicks3

  • 1Division of Cardiology, Department of Medicine, Duke University, Durham, North Carolina.

Journal of Cardiac Failure
|September 28, 2024
PubMed
Summary
This summary is machine-generated.

The baroreflex system regulates cardiovascular functions and its dysfunction is linked to diseases like hypertension. Targeting the baroreflex offers a new approach for managing cardiovascular conditions, but long-term studies are needed.

Keywords:
BATBaroreflexbaroreflex activation therapyheart failureneurocardiology

More Related Videos

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography
07:51

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography

Published on: September 22, 2011

28.5K
Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine
12:37

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine

Published on: February 9, 2016

13.4K

Related Experiment Videos

Last Updated: Jun 11, 2025

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
09:56

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

4.9K
Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography
07:51

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography

Published on: September 22, 2011

28.5K
Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine
12:37

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine

Published on: February 9, 2016

13.4K

Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Regulation

Background:

  • The baroreflex system is crucial for modulating cardiovascular functions, including blood pressure and cardiac output.
  • It also influences neurohormonal pathways like the renin-angiotensin-aldosterone system.
  • Baroreflex dysfunction, marked by sympathetic overactivation and parasympathetic withdrawal, is associated with hypertension, heart failure, and coronary artery disease.

Purpose of the Study:

  • To explore the role of the baroreflex system in cardiovascular regulation and disease.
  • To highlight the potential of baroreflex targeting as a therapeutic strategy for cardiovascular diseases.

Main Methods:

  • Review of existing literature on baroreflex physiology and dysfunction.
  • Examination of invasive (baroreflex activation therapy, endovascular baroreceptor amplification) and noninvasive (slow breathing, exercise training) baroreflex targeting strategies.

Main Results:

  • Baroreflex dysfunction contributes to sympathetic overactivity and parasympathetic withdrawal in cardiovascular diseases.
  • Both invasive and noninvasive interventions targeting the baroreflex show promise in managing cardiovascular conditions.

Conclusions:

  • Targeting the baroreflex system presents a novel therapeutic avenue for cardiovascular diseases.
  • Further research is required to assess the long-term safety and efficacy of these interventions across diverse cardiovascular conditions.