Related Experiment Video
Updated: Jun 11, 2025

14:58
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
9.6K
Uterine arteriovenous malformation: a case report with proposal for pathogenesis
Haomeng Zhang1, Shuman Sheng2, Wei Liu1
1Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
BMC Women'S Health
|September 28, 2024
Summary
Uterine arteriovenous malformation (UAM) is rare but causes severe hemorrhage. This case study details diagnosis and treatment for an elderly patient, proposing a new hypothesis for UAM development.
Area of Science:
- Reproductive medicine
- Vascular disorders
- Gynecologic pathology
Background:
- Uterine arteriovenous malformation (UAM) is a rare vascular anomaly.
- UAM can lead to life-threatening uterine hemorrhage.
- Lack of treatment consensus is due to low incidence, unknown causes, and varied patient fertility needs.
Observation:
- Presents an uncommon case of UAM in an elderly woman.
- Details the diagnostic process for UAM.
- Describes the treatment approach for this specific patient.
Findings:
- Discusses the clinical experience with UAM diagnosis and treatment.
- Proposes a novel hypothesis for the pathogenesis of UAM.
- Highlights the challenges in managing UAM due to its rarity.
Implications:
- Contributes to understanding UAM etiology and management.
- Informs clinical practice for rare uterine vascular conditions.
- May guide future research into UAM pathogenesis and treatment strategies.
Related Concept Videos
Mechanism of Angiogenesis
5.3K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.3K
Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
Aneurysm I: Introduction
3
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
3
Development of Blood Vessels
540
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
540

