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  11. Altered Oxidant And Antioxidant Levels Are Associated With Vascular Stiffness And Diabetic Kidney Disease In Type 1 Diabetes After Exposure To Acute And Chronic Hyperglycemia

Altered oxidant and antioxidant levels are associated with vascular stiffness and diabetic kidney disease in type 1 diabetes after exposure to acute and chronic hyperglycemia

Krishna Adeshara1,2, Elyse Di Marco1,2,3, Marco Bordino1,2

  • 1Folkhälsan Research Center, Biomedicum Helsinki, Haartmaninkatu 8, FIN-00290, Helsinki, Finland.

Cardiovascular Diabetology
|September 28, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Oxidative stress markers correlate with vascular stiffness and kidney disease in type 1 diabetes. These biomarkers, alongside HbA1c, can improve understanding and prediction of diabetes complications.

Area of Science:

  • Endocrinology
  • Nephrology
  • Cardiovascular Medicine

Background:

  • Hyperglycemia-induced oxidative stress is a key factor in diabetic vascular complications.
  • This study investigates plasma oxidant and antioxidant levels in type 1 diabetes (T1D) individuals.
  • The assessment relates these levels to vascular stiffness and diabetic kidney disease (DKD).

Purpose of the Study:

  • To assess plasma oxidant and antioxidant levels in response to acute and chronic hyperglycemia in T1D.
  • To evaluate the relationship between these levels, vascular stiffness, and varying degrees of DKD.
  • To determine if oxidative stress markers offer additional value beyond HbA1c for understanding T1D pathology.

Main Methods:

  • Compared oxidant/antioxidant levels (MDA, ROMs, TAC, BAP, SOD) in T1D individuals and controls under acute hyperglycemia (clamp study).
Keywords:
Antioxidant capacityArterial stiffnessDiabetesDiabetic kidney disease

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  • Analyzed plasma samples from the FinnDiane study cohort (118 T1D individuals) with varying HbA1c and DKD.
  • Correlated oxidative stress markers with vascular stiffness (AIx) and albumin excretion rate (AER).

    • Main Results:

    • Elevated baseline MDA and ROMs in T1D individuals; acute hyperglycemia increased MDA and sustained ROMs.
    • Acute hyperglycemia reduced TAC in both T1D and controls, while BAP increased in T1D.
    • Positive associations found between MDA/ROMs and vascular stiffness (AIx). Elevated ROMs and reduced antioxidant capacity were observed in T1D with high HbA1c and severe albuminuria.

    Conclusions:

    • Biomarkers of oxidative stress are linked to vascular stiffness and DKD in T1D patients exposed to hyperglycemia.
    • These markers may enhance the predictive value of HbA1c for disease progression and complications.
    • Oxidative stress assessment could aid in understanding T1D pathology and managing secondary complications.
    Hyperglycemia
    Oxidative stress