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How to utilize current guidelines to manage patients with cancer at high risk for heart failure

Michelle Bloom1, Jose A Alvarez-Cardona1, Sarju Ganatra2

  • 1Leon H. Charney Division of Cardiology, New York University School of Medicine, NYU Langone Health, New York, NY, USA.

Cardio-Oncology (London, England)
|September 28, 2024
PubMed

Insights

Cancer survivors face increased risks of heart failure (HF) and cardiovascular disease (CVD). Early detection and prevention strategies, guided by European Society of Cardiology (ESC) guidelines, are crucial for managing these conditions in patients undergoing cancer therapy.

Area of Science:

  • Cardio-Oncology
  • Cardiovascular Disease in Cancer Survivors

Background:

  • Cancer therapies improve survival but increase long-term cardiovascular disease (CVD) risks.
  • Cardiovascular disease (CVD), including heart failure (HF) and cardiomyopathy (CM), is a leading cause of mortality in cancer survivors.
  • European Society of Cardiology (ESC) guidelines offer a framework for managing cardiovascular (CV) health during and after cancer treatment.

Purpose of the Study:

  • To summarize key aspects of the ESC Cardio-Oncology (CO) guidelines relevant to HF clinicians.
  • To emphasize risk stratification, early detection, and prevention of CM and HF in cancer patients.
  • To highlight the role of guideline-directed medical therapy (GDMT) in managing HF in this population.

Main Methods:

  • Case study utilization to illustrate ESC guideline principles.
  • Focus on risk stratification, early detection, and prevention strategies.
  • Review of GDMT applications for HF in cancer patients.

Main Results:

  • Cancer patients require vigilant CV monitoring due to treatment-related risks.
  • Proactive risk stratification and early detection of CM/HF are essential.
  • ESC guidelines provide a comprehensive approach to CV care throughout the cancer journey.

Conclusions:

  • Integrating CO principles into HF clinical practice is vital.
  • Timely intervention and GDMT can mitigate HF morbidity and mortality in cancer patients.
  • Adherence to ESC guidelines improves outcomes for cancer survivors at risk of HF.

Keywords:
Cancer therapy related cardiac dysfunctionCardio-OncologyCardiomyopathyGuideline directed medical therapyHeart FailurePrevention

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