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Determination of Mandibular Morphology in a Turkish Population With Bipolar I Disorder Using Panoramic Radiography
Hakan Bahadir1, Nihal Yetimoğlu2, Özlem Oflezer3
1Department of Radiology, Private Practice, Istanbul, Turkey.
The Journal of Nervous and Mental Disease
|September 29, 2024
Summary
Mandibular morphology differences in bipolar disorder (BD) patients suggest abnormal neurodevelopment. Specific facial measurements like ramus height and bigonial width can help distinguish individuals with BD from controls.
Area of Science:
- Neuroscience
- Psychiatry
- Anthropology
Background:
- Craniofacial deviations may indicate abnormal brain development in bipolar disorder (BD).
- Understanding these links can offer insights into BD's neurodevelopmental origins.
Purpose of the Study:
- To compare mandibular morphology in bipolar disorder patients versus controls.
- To identify specific craniofacial measurements associated with BD.
Main Methods:
- Panoramic radiography was used to analyze mandibular parameters in 70 BD patients and 145 controls.
- Seven key mandibular measurements were assessed in a blinded manner, separately for males and females.
Main Results:
- Males with BD showed increased ramus height (RH), condylar height (CH), antegonial notch depth (AND), ramal notch depth (RND), and bigonial width (BGW), with decreased gonial angle (GA).
- Females with BD exhibited higher RH, CH, RND, and BGW compared to controls.
- Multivariate analysis identified increased RH and BGW as significant predictors for both sexes, while deeper AND was most predictive for males.
Conclusions:
- Subtle changes in mandibular measurements are linked to impaired neurodevelopment in bipolar disorder.
- Mandibular morphology analysis may serve as a potential biomarker for identifying individuals with BD.
