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Snail Expression as a Prognostic Factor in Colorectal Adenocarcinoma
Gina Andyka Hutasoit1,2, Upik Anderiani Miskad1,3, Fardah Akil4
1Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Indonesia.
Asian Pacific Journal of Cancer Prevention : APJCP
|September 29, 2024
Summary
Snail expression is linked to tumor progression in colorectal adenocarcinoma. Higher Snail levels correlate with increased tumor budding, lymphovascular invasion, and metastases, suggesting its potential as a prognostic marker.
Area of Science:
- Oncology
- Molecular Biology
- Pathology
Background:
- Colorectal adenocarcinoma is a significant cause of cancer-related mortality.
- Understanding molecular markers for prognosis is crucial for effective treatment strategies.
Purpose of the Study:
- To investigate the expression of Snail in colorectal adenocarcinoma tissues.
- To determine the correlation between Snail expression and key clinicopathological features.
Main Methods:
- A cross-sectional study involving 74 colorectal adenocarcinoma samples.
- Immunohistochemical analysis using a Snail rabbit polyclonal antibody.
- Statistical analysis (Mann Whitney test) to assess relationships with tumor grade, budding, invasion, and metastasis.
Main Results:
- Snail expression showed a significant positive correlation with tumor budding grade (p=0.003).
- Strong Snail expression was significantly associated with lymphovascular invasion and metastases (p<0.001).
- No significant correlation was found between Snail expression and histopathological grade (p=0.942).
Conclusions:
- Snail expression serves as a potential prognostic factor in colorectal adenocarcinoma.
- Elevated Snail levels indicate a more aggressive tumor phenotype.
