Recent advances in AIE-based platforms for cancer immunotherapy

Area of Science:

• Nanomedicine
• Biomedical Engineering
• Immunology

Background:

• Aggregation-induced emission luminogens (AIEgens) exhibit enhanced fluorescence and photostability when aggregated.
• AIEgens are emerging as powerful tools in nanomedicine for theranostics, particularly in cancer treatment.

Purpose of the Study:

• To review the integration of AIEgens in nanomedicine for cancer immunotherapy.
• To highlight the advantages, mechanisms, and advancements of AIEgens as therapeutic platforms.

Main Methods:

• Literature review of AIEgens in nanomedicine and cancer immunotherapy.
• Analysis of AIEgens' role in immune response modulation and synergistic therapies.

Main Results:

• AIEgens facilitate real-time image-guided therapy, induce cell death, and reprogram the tumor microenvironment.
• AIEgens enhance cancer immunotherapy by modulating immune responses and potentiating immune checkpoint inhibition.

Conclusions:

• AIEgens represent a promising platform for advanced cancer immunotherapy, offering versatile applications in nanomedicine.
• Further research into AIEgens will drive innovation in phototheranostics and personalized cancer treatment.