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Updated: Jun 11, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Associations of adipose tissue depots with cardiac resynchronization therapy response and clinical outcomes: A CRT-HF

Maximilian C Volk1, Saeid Mirzai2, Ian Persits1

  • 1Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.

Journal of Cardiology
|September 29, 2024
PubMed

Insights

Subcutaneous fat deposition improves cardiac resynchronization therapy (CRT) response in heart failure (HF) patients. Intramuscular adiposity, however, is linked to increased frailty, suggesting distinct roles for fat distribution in HF outcomes.

Area of Science:

  • Cardiology
  • Metabolic Health
  • Medical Imaging

Background:

  • Regional adipose tissue distribution significantly impacts heart failure (HF) patient prognosis.
  • The specific effects of regional adiposity on outcomes for HF patients receiving cardiac resynchronization therapy (CRT) are not well understood.

Purpose of the Study:

  • To investigate the association between regional adiposity and clinical outcomes in patients with heart failure undergoing CRT.
  • To determine if subcutaneous, intramuscular, or hepatic fat deposition influences CRT response and frailty.

Main Methods:

  • Retrospective analysis of 95 heart failure patients who underwent CRT.
  • Utilized multi-slice computed tomography (CT) for pre-CRT body composition and adipose tissue quantification.
  • Stratified patients based on levels of subcutaneous adiposity, intramuscular adiposity, and hepatic steatosis.

Main Results:

  • Higher subcutaneous adiposity was significantly correlated with improved CRT response rates (44.4% vs 16.7%, p=0.009).
  • Increased intramuscular adiposity was associated with a higher likelihood of pre-frailty (adjusted OR 14.17, p=0.005).

Conclusions:

  • Subcutaneous fat may be protective in heart failure, potentially enhancing CRT efficacy.
  • Intramuscular adiposity could serve as a predictive biomarker for frailty in heart failure patients.
  • Regional fat distribution plays a critical role in HF patient management and therapeutic response.
Abstract

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