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Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Updated: Jun 11, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

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ENPP1 deficiency: almost ready for prime time!

Justine Bacchetta¹, Cyril Amouroux²

¹Service de Néphrologie, Rhumatologie et Dermatologie Pédiatriques, Hôpital Femme Mère Enfant, Boulevard Pinel, 69677 Bron Cedex, France; Unité de Néphrologie et Endocrinologie, Service de Pédiatrie Multidisciplinaire, CHU de Montpellier, 371 avenue du Doyen Gaston Giraud, 34000 Montpellier France; Centre national de Référence des Maladies rares du Métabolisme du Calcium et du Phosphate, Filière de Santé Maladies Rares OSCAR https://www.filiere-oscar.fr; INSERM 1033 Research Unit; Lyon 1 University, Lyon, France; Département de Pédagogie, Faculté de Médecine Montpellier-Nimes, Université de Montpellier, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|September 29, 2024

Summary

No abstract available in PubMed .

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