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Updated: May 6, 2026

Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
Published on: September 5, 2017
A multidisciplinary view of flash irradiation
Flavia Gesualdi1, Ludovic de Marzi2, Marie Dutreix3
1Institut Curie, Hospital Division, centre de protonthérapie d'Orsay, université Paris-Saclay, université PSL, centre universitaire, 91948 Orsay cedex, France.
Abstract:
The delivery of ultra-high dose rates of radiation, called flash irradiation or flash-RT, has emerged as a new modality of radiotherapy shaking up the paradigm of proportionality of effect and dose whatever the method of delivery of the radiation. The hallmark of flash-RT is healthy tissue sparing from the side effects of radiation without decrease of the antitumor efficiency in animal models. In this review we will define its specificities, the molecular mechanisms underlying the flash effect and the ongoing developments to bring this new modality to patient treatment.
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