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Diagnostic performances of the Ovarian Adnexal Reporting and Data System, the Risk of Ovarian Malignancy Algorithm, and the Copenhagen Index in the preoperative prediction of ovarian cancer: a prospective cohort study

  • 0Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
Journal of Gynecologic Oncology +

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September 30, 2024

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September 30, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

The Risk of Ovarian Malignancy Algorithm (ROMA), Copenhagen Index (CPH-I), and Ovarian Adnexal Reporting and Data System (O-RADS) show promise for predicting ovarian cancer (OC). Combining O-RADS with CA125 offered the highest diagnostic accuracy for preoperative OC detection.

Area Of Science

  • Gynecologic Oncology
  • Diagnostic Imaging
  • Biomarker Research

Background

  • Early and accurate diagnosis of ovarian cancer (OC) is crucial for improving patient outcomes.
  • Preoperative risk stratification tools are essential for guiding clinical management decisions.

Purpose Of The Study

  • To evaluate the diagnostic performance of the Risk of Ovarian Malignancy Algorithm (ROMA), Copenhagen Index (CPH-I), and Ovarian Adnexal Reporting and Data System (O-RADS) in the preoperative prediction of OC.
  • To compare the efficacy of these algorithms, alone and in combination with biomarkers (CA125, HE4), for OC diagnosis.

Main Methods

  • A prospective cohort study involving 462 patients with ovarian tumors.
  • Calculation of ROMA and CPH-I using CA125, HE4, age, and menopausal status.
  • Application of O-RADS criteria based on ultrasound findings.
  • Comparison of diagnostic performance against histopathological results.

Main Results

  • O-RADS (≥3) demonstrated a high area under the curve (AUC) of 0.949 with sensitivity/specificity (Se/Sp) of 88.52%/88.98%.
  • The combination of O-RADS with CA125 achieved the highest AUC of 0.969, with Se/Sp of 98.36%/86.09%.
  • ROMA and CPH-I also showed good predictive values, with AUCs of 0.880 and 0.890, respectively.

Conclusions

  • ROMA, CPH-I, and O-RADS are effective tools for preoperative OC prediction.
  • The combination of O-RADS and CA125 provides superior diagnostic performance for identifying ovarian cancer.
  • These findings support the integration of O-RADS and CA125 in the preoperative assessment of ovarian tumors.

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