Uveitis: A snapshot in the MOG antibody spectrum
Claudia Fabiani1, Gian Marco Tosi1, Valentina Damato2
1Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Policlinico "Le Scotte," Siena, Italy.
Multiple Sclerosis (Houndmills, Basingstoke, England)
|September 30, 2024
Summary
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) can present with uveitis alongside optic neuritis. This case highlights the importance of personalized treatment for ocular inflammation in MOGAD.
Area of Science:
- Neuroimmunology
- Ophthalmology
Background:
- Myelin oligodendrocyte glycoprotein (MOG) antibodies are typically linked to optic neuritis.
- The association between MOG antibodies and uveitis remains under-investigated.
Observation:
- A 41-year-old male presented with uveitis and bilateral optic neuritis.
- The patient was diagnosed with MOG antibody-associated disease (MOGAD).
Findings:
- This case demonstrates bilateral optic neuritis and unilateral anterior uveitis in MOGAD.
- The findings contribute to understanding intraocular inflammation patterns in MOGAD.
Implications:
- Personalized treatment strategies are crucial for MOGAD-associated ocular manifestations.
- Rituximab showed efficacy in a patient with contraindications to oral steroids.
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