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Updated: May 1, 2026
FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
[Expert consensus on the application of digital PCR non-invasive prenatal screening technology for the preliminary
Peng Dai1, Chen Chen, Ganye Zhao
1Genetics and Prenatal Diagnosis Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450012, China. kongxd@263.net.
Abstract:
Clinical application of serological screening and non-invasive prenatal testing (NIPT) both have difficulties to attain high detection rate and low cost. For its advantages of high detection rate, high sensitivity, simplicity, short turnaround time and low cost, digital PCR (dPCR) has provided a new choice for prenatal screening of trisomies 21, 18 and 13. To standardize the application of dPCR for prenatal screening, we have formulated this consensus by referring to relevant guidelines, expert consensus and latest literature, which has covered the basic requirements, application scope, pre-testing service, testing procedure, report interpretation, genetic counseling, and limitations for this technology.
