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[Research progress on GSDME-mediated cell pyroptosis resulting in GSDME type hearing loss]
Liting Peng1, Xi Wang, Weiqian Wang
1Department of Otolaryngology, Chinese People's Liberation Army Rocket Force Special Medical Center, Beijing 100088, China. mixueer0110@126.com.
Abstract:
Pyroptosis is a novel mode for programmed cell death discovered and confirmed in recent years. The Gasdermins (GSDMs) family is a key effector molecule mediating pyroptosis. As an important cause of extensive inflammatory damage and side effects of conventional chemotherapy drugs, anomalous pyroptosis has also been associated with hearing loss, tumor, and disorders of the immune system. The GSDME protein, encoded by the GSDME (DFNA5) gene, belongs to the GSDMs family and is a key factor mediating pyroptosis. Gain-of-function variants of the GSDME gene can lead to GSDME-related hearing loss, which shows an autosomal dominant inheritance. This article has reviewed the role of GSDME-mediated pyroptosis in the pathogenesis of GSDME-related hearing loss, with an aim to provide insights into the treatment of GSDME-related hearing loss.
Insights
Gasdermin E (GSDME)-mediated pyroptosis is implicated in GSDME-related hearing loss. Understanding this programmed cell death pathway offers insights into treating this condition.
Area of Science:
- Molecular Biology
- Genetics
- Cellular Biology
Background:
- Pyroptosis is a programmed cell death pathway.
- Gasdermin family proteins are key mediators of pyroptosis.
- Anomalous pyroptosis is linked to various pathologies, including hearing loss.
Purpose of the Study:
- To review the role of GSDME-mediated pyroptosis in GSDME-related hearing loss.
- To provide insights into potential therapeutic strategies for GSDME-related hearing loss.
Main Methods:
- Literature review focusing on GSDME, pyroptosis, and hearing loss.
- Analysis of genetic and molecular mechanisms underlying GSDME-related hearing loss.
Main Results:
- Gain-of-function variants in the GSDME gene cause GSDME-related hearing loss.
- GSDME-mediated pyroptosis is a key factor in the pathogenesis of this condition.
- GSDME-related hearing loss exhibits autosomal dominant inheritance.
Conclusions:
- GSDME-mediated pyroptosis plays a critical role in GSDME-related hearing loss.
- Targeting GSDME or pyroptosis pathways may offer therapeutic benefits for hearing loss.
