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Related Experiment Video

Updated: Jun 11, 2025

Monitoring Blood-Brain Barrier Opening in Rats with a Preclinical Focused Ultrasound System
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Published on: September 13, 2024

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Monitoring Blood-Brain Barrier Opening in Rats with a Preclinical Focused Ultrasound System.

Kisoo Kim1, Marco Gallus2, Tianrun Xiao3

  • 1Department of Radiology & Biomedical Imaging, University of California, San Francisco; Department of Biomedical Engineering, Kyung Hee University; kisoo.kim@khu.ac.kr.

Journal of Visualized Experiments : Jove
|September 30, 2024
PubMed
Summary

This study presents a reproducible method using focused ultrasound (FUS) and MRI to open the blood-brain barrier (BBB) in rats. This technique enhances drug delivery for neurological disorder treatments.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Radiology

Background:

  • The blood-brain barrier (BBB) restricts therapeutic agent delivery to the brain.
  • Focused ultrasound (FUS) with microbubbles offers non-invasive BBB modulation.
  • MRI provides detailed assessment of BBB status and agent distribution.

Purpose of the Study:

  • To establish and validate a reproducible MRI-guided FUS methodology for monitoring BBB opening in a rat model.
  • To streamline preclinical procedures for BBB modulation research.
  • To facilitate enhanced therapeutic delivery for neurological disorders.

Main Methods:

  • Utilized MR-guided low-intensity pulsed focused ultrasound (FUS) with microbubble pre-injection in a rat model.
  • Developed comprehensive MRI protocols for monitoring BBB opening, including contrast-enhanced imaging.
  • Employed a stereotactic-guided preclinical FUS transducer for precise targeting and procedure refinement.

Main Results:

  • Demonstrated a reproducible and simplified methodology for BBB opening monitoring.
  • Validated the use of MRI as a gold standard for detecting BBB opening.
  • Rat model facilitated jugular vein catheterization for rapid administration.

Conclusions:

  • The developed MRI-guided FUS method is reproducible and requires no specialized surgical expertise.
  • This approach optimizes preclinical BBB modulation studies in rat models.
  • Enhances potential for improved therapeutic interventions in neurological diseases.