The temporary impact of COVID-19 on semen deoxyribonucleic acid fragmentation
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View abstract on PubMed
Summary
This summary is machine-generated.Coronavirus disease 2019 (COVID-19) significantly increases semen DNA fragmentation in both vaccinated and unvaccinated men. This DNA damage peaks two months post-recovery and takes longer to normalize in unvaccinated individuals.
Area Of Science
- Reproductive medicine
- Infectious diseases
- Genetics
Background
- Coronavirus disease 2019 (COVID-19) affects multiple body systems.
- Recent development of anti-COVID vaccines.
Purpose Of The Study
- To investigate the impact of COVID-19 on semen DNA fragmentation.
- To compare the effects in vaccinated versus unvaccinated males.
Main Methods
- Study included 46 vaccinated and 43 unvaccinated males infected with COVID-19.
- Semen DNA Fragmentation Index (SDFI) measured pre-infection and monthly post-recovery.
- Mann-Whitney test used for statistical analysis (p <0.05).
Main Results
- SDFI significantly increased post-COVID-19 in both groups compared to baseline.
- SDFI peaked at 2 months post-recovery (40.6% in vaccinated, 49.7% in unvaccinated).
- SDFI normalized by 7 months in vaccinated and 9 months in unvaccinated men.
Conclusions
- COVID-19 leads to a progressive increase in semen DNA fragmentation.
- The effect is more pronounced and prolonged in unvaccinated individuals.
- Vaccination may aid in faster recovery of semen quality parameters.
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