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Updated: Jun 11, 2025

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
Published on: June 28, 2019
Improved Syntheses of an Arseno-Fatty Acid (As-FA 362) and an Arseno-Hydrocarbon (As-HC 444)
Miguel A Chacon-Teran1, Shubhra Bhattacharjee2, Jeremy D Bailoo3
1Department of Chemistry and Biochemistry, University of California, Merced, 5200 Lake Rd, Merced, CA 95343, USA.
Abstract:
Robust and reliable synthetic methods have been developed for the preparation of an arseno-fatty acid (As-FA362) and an arseno-hydrocarbon (As-HC444). An improved route to access the starting materials necessary for the new synthetic routes is also disclosed. With these improvements, an increased accessibility to arsenic-containing compounds is anticipated, which may be deployed as standards required for the development of quantitative methods in biological matrices. For the first time, stability data for these compounds are reported. With these results in hand, data on the elimination profile, bioaccumulation potential and patho-behavioral and physiological consequences of these organoarsenicals are planned.
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