Selective loss of Y chromosomes in lung adenocarcinoma modulates the tumor immune environment through cancer/testis antigens
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View abstract on PubMed
Summary
This summary is machine-generated.Loss of the Y chromosome (LOY) in aging men impacts heart health and cancer. In lung adenocarcinoma, LOY influences tumor immunity and predicts response to immunotherapy.
Area Of Science
- Genetics and Genomics
- Oncology
- Immunology
Background
- Sex chromosomes (X and Y) influence health beyond sex determination.
- Loss of the Y chromosome (LOY) is linked to cardiac issues and poorer cancer survival.
- LOY occurs in male solid tumors, potentially conferring a growth advantage.
Purpose Of The Study
- To investigate the role of LOY in lung adenocarcinoma (LUAD).
- To determine if LOY impacts the tumor immune microenvironment and immune evasion.
- To assess LOY as a biomarker for immunotherapy response in male LUAD patients.
Main Methods
- Analysis of LOY in LUAD using bulk and single-cell expression data.
- Examination of cancer/testis antigen expression in relation to LOY.
- Evaluation of immunotherapy data, including response to pembrolizumab.
Main Results
- LOY in LUAD is associated with altered cancer/testis antigen expression.
- These alterations suggest LOY facilitates tumor immune evasion.
- LOY and specific cancer/testis antigen expression correlate with pembrolizumab treatment response and outcomes.
Conclusions
- LOY plays a significant role in the LUAD tumor immune microenvironment.
- LOY and associated antigen expression changes are potential biomarkers for predicting immunotherapy response in males.
- This finding offers a novel approach for personalizing LUAD treatment.
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