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DC-derived whole cell cytokine nano-regulator for remodelling extracellular matrix and synergizing tumor
Jingsong Lu1, Ying Li2, Xiaohan Gao2
1Department of Chemistry, Tsinghua University Beijing 100084 China lujingsong2022@mail.tsinghua.edu.cn weiyen@tsinghua.edu.cn.
Abstract:
A smart dendritic cell (DC)-derived whole cell cytokine (DWC) nano-regulator of TCPs was developed for tumor cytokine-immunotherapy. The DWCs were purified from activated DC-cultured media and applied as a nano-dosage form. It was found that TCPs could remodel extracellular matrices via the elimination of fibronectin and type I collagen (Col-I) in tumor tissues, as well as the inhibition of α-SMA expression in cancer associated fibroblasts (CAFs). Furthermore, after local TCP treatment, significant tumor inhibition could be achieved combined with radiotherapy.
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