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Published on: August 11, 2023
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Exploring Factors Influencing Stroke Risk: Insights From a Predictive Analysis.
Venkatram Murugesan1, Murugesan Natesan1, Vahidha Sulthana1
1Nephrology, East Coast Hospitals, Pondicherry, IND.
Cureus
|September 30, 2024
Summary
This study found that while higher fasting insulin levels may reduce stroke risk, increased postprandial insulin and age are associated with a higher risk. These findings highlight the complex role of insulin in stroke occurrence.
Area of Science:
- Endocrinology
- Neurology
- Cardiovascular Medicine
Background:
- Stroke is a leading cause of disability and mortality globally, with numerous modifiable and non-modifiable risk factors.
- Understanding the intricate relationship between metabolic markers, such as insulin levels, and stroke occurrence is crucial for effective prevention strategies.
Purpose of the Study:
- To investigate the association between fasting and postprandial insulin levels and stroke occurrence in a cohort of 229 patients.
- To identify key predictors of stroke risk within the studied population.
Main Methods:
- Retrospective analysis of clinical data from 229 patients, including demographic information, medical history, and various blood glucose and insulin measurements.
- Logistic regression analysis was employed to model the relationship between insulin levels, age, and stroke occurrence, accounting for an imbalanced outcome variable.
Main Results:
- Increasing postprandial insulin levels and age were significantly associated with an increased risk of stroke.
- Conversely, higher fasting insulin levels were linked to a reduced risk of stroke.
- Blood glucose, cholesterol, and triglyceride levels demonstrated minor associations with stroke occurrence, with higher total cholesterol and triglycerides showing a slight association with lower stroke risk.
Conclusions:
- Age and postprandial insulin levels are identified as significant risk factors for stroke.
- Fasting insulin levels may play a protective role, warranting further investigation.
- Additional research with larger sample sizes is recommended to validate these findings and elucidate the complex role of insulin in stroke pathophysiology.
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