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Risk Factors and VEGF, hs-CRP, and ESR in Central Serous Chorioretinopathy
Lingjuan Sun1, Li Yin1, Shurui Wang1
1Department of Ophthalmology Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050000, China.
Insights
Male gender, shift work, Helicobacter pylori infection, and hypothyroidism are key risk factors for central serous chorioretinopathy (CSC). Elevated vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP), and erythrocyte sedimentation rate (ESR) also indicate increased CSC risk and aid diagnosis.
Area of Science:
- Ophthalmology
- Medical Research
- Biomarkers
Background:
- Central serous chorioretinopathy (CSC) is a condition affecting vision.
- Identifying risk factors and reliable diagnostic markers for CSC is crucial for patient management.
Purpose of the Study:
- To investigate risk factors associated with CSC.
- To analyze the relationship between vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and CSC.
- To evaluate the diagnostic value of these biomarkers in CSC.
Main Methods:
- A case-control study included 109 CSC patients and 103 controls.
- Demographic data, medical history, and lifestyle factors were collected.
- VEGF, hs-CRP, and ESR levels were measured; logistic regression and ROC curve analyses were performed.
Main Results:
- CSC patients had higher rates of male gender, smoking, alcohol consumption, obstructive sleep apnea, hypothyroidism, renal disease, H. pylori infection, steroid use, and shift work.
- Significantly elevated VEGF, hs-CRP, and ESR levels were observed in CSC patients compared to controls.
- Male gender, shift work, H. pylori infection, hypothyroidism, and elevated VEGF, hs-CRP, and ESR were identified as independent risk factors for CSC.
Conclusions:
- Male gender, shift work, H. pylori infection, and hypothyroidism are significant risk factors for CSC.
- Elevated VEGF, hs-CRP, and ESR levels are associated with CSC and demonstrate diagnostic value.
- Combined assessment of VEGF, hs-CRP, and ESR offers enhanced diagnostic efficiency for CSC.
Objective:
This study aimed to investigate the risk factors associated with central serous chorioretinopathy (CSC) and analyze the relationship between vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and CSC.
Methods:
A total of 109 patients diagnosed with CSC (CSC group) at our ophthalmology clinic from February 2017 to February 2021 were included, with 103 volunteers from our hospital's health examination center serving as the control group. Additionally, the new multimodal imaging classification of 109 CSC patients was further divided into simple CSC (57 cases) and complex CSC (52 cases). Demographic data, underlying diseases, medical history, and medication history were collected. Levels of VEGF, hs-CRP, and ESR were measured, and multifactorial logistic regression analysis was performed to identify factors influencing CSC. Receiver operating characteristic (ROC) curve analysis was conducted to assess the diagnostic value of VEGF, hs-CRP, and ESR in CSC.
Results:
The CSC group showed a higher proportion of males, smoking history, alcohol consumption, comorbid obstructive sleep apnea, hypothyroidism, renal disease, Helicobacter pylori infection, steroid use, and shift work compared to the control group (P < 0.05). VEGF, hs-CRP, and ESR levels were significantly higher in the CSC group than in the control group (P < 0.05). The levels of VEGF, hs-CRP, and ESR in the complex CSC group were higher than those in the simple CSC group (P < 0.05). Male gender, shift work, Helicobacter pylori infection, hypothyroidism, elevated VEGF, hs-CRP, and ESR were identified as risk factors for CSC (P < 0.05). The combined diagnostic value of VEGF, hs-CRP, and ESR (area under the ROC curve: 0.886) was higher than that of individual markers (0.722, 0.728, and 0.703, respectively) (P < 0.05).
Conclusion:
Male gender, shift work, Helicobacter pylori infection, hypothyroidism, and elevated levels of VEGF, hs-CRP, and ESR are risk factors for CSC. The combined use of VEGF, hs-CRP, and ESR demonstrates higher diagnostic efficiency in identifying CSC.
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