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Association of Angina, Myocardial Infarction and Atrial Fibrillation-A Bidirectional Mendelian Randomization Study

Lu Chen1,2, Yan He2, Ying Wang2

  • 1Department of Cardiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.

British Journal of Hospital Medicine (London, England : 2005)
|September 30, 2024
PubMed

Insights

Coronary atherosclerosis and heart attacks may increase atrial fibrillation risk. Atrial fibrillation may also raise coronary atherosclerosis risk, suggesting a bidirectional causal link.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Epidemiology

Background:

  • Coronary heart disease (CHD) and atrial fibrillation (AF) are closely linked.
  • Observational studies limit establishing causal relationships between CHD and AF.
  • Causal links between coronary atherosclerosis (CAAs), angina pectoris, myocardial infarction (MI), and AF require investigation.

Purpose of the Study:

  • To investigate the causal relationships between CAAs, angina, MI, and AF.
  • To utilize Mendelian randomization to assess causality between cardiovascular conditions and AF.

Main Methods:

  • Two-sample Mendelian randomization (TSMR) methodology.
  • Leveraging genetic variation to infer causal relationships.
  • Adherence to Mendelian randomization assumptions for validity.

Main Results:

  • Genetic predisposition suggests CAAs, angina, and MI increase susceptibility to AF.
  • Evidence indicates AF may reciprocally elevate the risk of CAAs.
  • Findings suggest a potential bidirectional causal relationship.

Conclusions:

  • Patients with CHD should have regular cardiac rhythm monitoring.
  • Patients with AF should receive feasible anticoagulant and antiplatelet therapy.
  • The study offers practical implications for clinical management of cardiovascular diseases.

Keywords:
Mendelian randomizationanginaatrial fibrillationcoronary arterial atherosclerosisgeneticsmyocardial infarction

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