Lactobionic acid matrix supramolecular complexes with enhanced bioavailability and clinical efficacy as an optimal CP...

Area of Science:

• Biochemistry
• Materials Science
• Chemical Engineering

Background:

• Lactobionic acid (LBA) exhibits biological activity but suffers from poor bioavailability.
• Addressing low LBA bioavailability is crucial for its effective application in various fields.

Purpose of the Study:

• To synthesize a novel supramolecular lactobionic acid (SLBA) formulation.
• To significantly improve the bioavailability and efficacy of LBA.

Main Methods:

• Computer high-throughput screening and ab initio analysis to identify suitable compounds.
• Synthesis of SLBA via a proton exchange reaction between LBA, betaine, and mandelic acid.
• Density functional theory and physicochemical characterization to confirm supramolecular structure and stability.

Main Results:

• Successfully synthesized SLBA with significantly enhanced LBA bioavailability.
• Demonstrated superior performance of SLBA over LBA in cellular, animal, and clinical trials.
• Confirmed the supramolecular nature and chemical stability of the SLBA complex.

Conclusions:

• SLBA represents a breakthrough in overcoming LBA bioavailability limitations.
• SLBA shows vast potential for applications in anti-aging, clinical treatments, biomedicine, and food preservation.