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[Comparative effectiveness of the basic drugs used in rheumatoid arthritis (long-term randomized study)]
Terapevticheskii Arkhiv
|January 1, 1985
Summary
Gold salts are the most effective rheumatoid arthritis treatment. Other drugs like D-Penicillamine and delagil show less efficacy, while levamisole poses significant risks due to side effects.
Area of Science:
- Rheumatology
- Pharmacology
- Clinical Medicine
Background:
- Rheumatoid arthritis (RA) management relies on slow-acting drugs.
- Comparative efficacy data is crucial for treatment selection.
Purpose of the Study:
- To compare the efficacy of basic slow-acting drugs for rheumatoid arthritis.
- To evaluate the safety and effectiveness of different RA treatment options.
Main Methods:
- Randomized study design to ensure objective data collection.
- Comparative analysis of gold salts, D-Penicillamine, delagil, and levamisole.
Main Results:
- Gold salts (chrisanol, myochrysin) demonstrated the highest efficacy in RA treatment.
- D-Penicillamine and delagil exhibited lower efficacy.
- Levamisole use was associated with frequent and severe side effects, indicating potential danger.
Conclusions:
- Gold salts are the preferred basic slow-acting drugs for rheumatoid arthritis.
- D-Penicillamine and delagil are less effective alternatives.
- Levamisole is not recommended due to safety concerns in RA treatment.