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Hyperbaric liver dysfunction in saturation divers.

G R Doran, L Chaudry, A O Brubakk

    Undersea Biomedical Research
    |June 1, 1985
    PubMed
    Summary
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    High pressure during deep dives elevates thyroid hormones and glycoproteins, suggesting potential liver dysfunction in divers. These changes occur even at shallower depths, impacting diver well-being.

    Area of Science:

    • Hyperbaric Medicine
    • Biochemistry
    • Diving Physiology

    Background:

    • Previous studies indicated elevated thyroid hormones and transaminase activities during deep dives (540-660 msw).
    • These findings raised concerns about potential liver dysfunction induced by high compression.

    Purpose of the Study:

    • To investigate blood thyroid hormone level changes during sustained compression in controlled dives.
    • To explore the role of binding globulins and other glycoproteins in these observed hormonal alterations.

    Main Methods:

    • Analysis of blood samples from divers during controlled chamber dives at various depths (e.g., 61 msw, 540 msw, 660 msw).
    • Measurement of thyroid hormones (thyroxine, reverse triiodothyronine) and binding globulins (thyroxine-binding globulin, sex hormone-binding globulin, etc.).

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    Main Results:

    • Sustained compression, even at 61 msw, led to elevations in thyroxine and reverse triiodothyronine.
    • Thyroxine-binding globulin (TBG) levels increased during dives to 540 and 660 msw.
    • Elevated levels of multiple glycoproteins were observed, suggesting a systemic response within the liver.

    Conclusions:

    • Hyperbaric exposure causes significant alterations in thyroid hormone levels and glycoprotein concentrations.
    • These changes support the theory of hyperbaric liver dysfunction.
    • The findings have implications for understanding high-pressure nervous syndrome and diver safety.