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Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Rheumatic Heart Disease I: Introduction01:23

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Endocarditis II: Clinical features and Diagnostic Tests01:25

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Myocarditis II: Clinical features and Diagnostic Tests01:27

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Rheumatic Heart Disease III: Medical Management01:21

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Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Endocarditis I: Introduction01:25

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Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
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Serum Endocan Levels in Children with Acute Rheumatic Fever.

M T Doğan1, U Can2, H Alp3

  • 1Department of Pediatric Cardiology, Selcuk University, MD, Konya, Turkey.

Nigerian Journal of Clinical Practice
|September 30, 2024
PubMed
Summary
This summary is machine-generated.

Serum endocan levels increase during the subacute phase of acute rheumatic fever. Elevated endocan may serve as a biomarker for cardiac involvement severity in acute rheumatic fever patients.

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Area of Science:

  • Biochemistry
  • Immunology
  • Pediatrics

Background:

  • Acute rheumatic fever (ARF) is an autoimmune condition following group A streptococcus infection.
  • Understanding ARF's progression and identifying biomarkers are crucial for patient management.

Purpose of the Study:

  • To evaluate serum endocan levels in children with ARF.
  • To compare endocan levels between ARF patients and healthy controls.
  • To assess the correlation between endocan levels and disease severity/treatment.

Main Methods:

  • Recruited 23 children with ARF and 31 healthy controls.
  • Measured serum endocan levels, C-reactive protein, erythrocyte sedimentation rate, and antistreptolysin-O titres.
  • Compared endocan levels before and after anti-inflammatory therapy.

Main Results:

  • Before treatment, no significant difference in endocan levels between ARF patients and controls.
  • After anti-inflammatory therapy, endocan levels were significantly higher in ARF patients compared to controls (260.87 ng/L vs. 120.71 ng/L, P < 0.01).
  • Endocan levels increased significantly after therapy in ARF patients (200.64 ng/L vs. 260.87 ng/L, P = 0.033).
  • Higher endocan levels were observed in severe carditis cases post-therapy (344.56 ng/L vs. 191.01 ng/L, P < 0.01).

Conclusions:

  • Serum endocan levels rise during the subacute phase of ARF.
  • Endocan may serve as a novel biomarker for assessing cardiac involvement in ARF.
  • Further research can explore endocan's role in ARF pathogenesis and clinical monitoring.