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Hand Osteoarthritis and Subclinical Cardiovascular Disease in Middle-Aged Women

Rodrigo Rafael Flores-Marinelarena1,2, Tatiana Sofia Rodríguez-Reyna3, Carlos Cantú-Brito1,4

  • 1Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Mexico City, Mexico.

Journal of Women'S Health (2002)
|September 30, 2024
PubMed

Insights

Hand osteoarthritis (HOA) is linked to subclinical cardiovascular disease (sCVD) in middle-aged women. This finding suggests a potential connection between joint inflammation and arterial health, warranting further investigation.

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Epidemiology

Background:

  • Hand osteoarthritis (HOA) is a common condition in middle-aged women.
  • Cardiovascular disease (CVD) risk factors and subclinical CVD (sCVD) require better characterization in this demographic.
  • The association between HOA and sCVD is not well-established.

Purpose of the Study:

  • To determine the prevalence of sCVD in middle-aged women with clinically manifested HOA.
  • To investigate the relationship between HOA and sCVD.
  • To enhance the understanding of cardiovascular risk in women with HOA.

Main Methods:

  • Cross-sectional study of 1,803 volunteers from the Mexican Teachers' Cohort (2012-2016).
  • HOA assessed via questionnaire (age ≥45, hand joint pain, morning stiffness ≤30 min).
  • sCVD evaluated using carotid artery intima-media thickness (IMT) and atherosclerotic plaques via ultrasound.

Main Results:

  • 18.4% of participants had HOA; 23.1% had carotid atherosclerosis.
  • Women with HOA showed a 1.8% greater mean IMT compared to those without HOA.
  • HOA was associated with a 36% higher odds of carotid atherosclerosis.

Conclusions:

  • Hand osteoarthritis is significantly associated with subclinical cardiovascular disease in middle-aged women.
  • The link may involve chronic inflammation, but underlying mechanisms need further research.
  • These findings highlight the importance of considering cardiovascular risk in women diagnosed with HOA.

Keywords:
cardiovascular riskcarotid intima-media thicknessosteoarthritissubclinical atherosclerosis

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