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Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial
Emily N C Manoogian1, Michael J Wilkinson2, Monica O'Neal1
1Regulatory Biology, The Salk Institute for Biological Studies, La Jolla, California (E.N.C.M., M.O., K.L., N.R.G., S.P.).
Annals of Internal Medicine
|September 30, 2024
Summary
Time-restricted eating (TRE) modestly improves glycemic regulation in adults with metabolic syndrome. This 8- to 10-hour eating window intervention offers cardiometabolic benefits alongside standard care.
Area of Science:
- Metabolic Health
- Chronobiology
- Nutritional Science
Background:
- Metabolic syndrome poses significant cardiometabolic risks.
- Time-restricted eating (TRE) is a dietary pattern limiting intake to 8-10 hours daily.
- TRE shows potential for improving metabolic health without calorie restriction.
Purpose of the Study:
- To evaluate TRE as a lifestyle intervention for adults with metabolic syndrome.
- To assess TRE's effects when combined with standard-of-care treatments.
- To determine impacts on cardiometabolic health markers.
Main Methods:
- A randomized controlled trial (TIMET study) involving adults with metabolic syndrome.
- Participants received either standard nutritional counseling (SOC) or SOC plus a personalized 8-10 hour TRE intervention.
- Dietary intake timing was monitored using the myCircadianClock smartphone application.
Main Results:
- The TRE group showed a modest but statistically significant improvement in HbA1c (-0.10%) compared to SOC.
- Primary outcomes included HbA1c, fasting glucose, and insulin resistance measures.
- No major adverse events were reported during the 3-month intervention.
Conclusions:
- Personalized 8- to 10-hour TRE is a practical lifestyle intervention.
- TRE modestly improves glycemic regulation in adults with metabolic syndrome.
- TRE may offer broader cardiometabolic benefits when added to standard care.
