Related Experiment Video
Updated: Jun 11, 2025

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
Published on: April 4, 2016
Exploring the Role of Extrachromosomal Circular DNA in Human Diseases
Yali Peng1, Huihui Tao1,2,3, Guoying Wang1
1School of Medicine, Anhui University of Science and Technology, Huainan, China.
Background:
Extrachromosomal circular DNA (eccDNA) has emerged as a central focus in molecular biology, with various types being found across species through advanced techniques, including high-throughput sequencing. This dynamic molecule exerts a significant influence on aging and immune function and plays pivotal roles in autoimmune diseases, type 2 diabetes mellitus, cancer, and genetic disorders.
Summary:
This comprehensive review investigates the classification, characteristics, formation processes, and multifaceted functions of eccDNA, providing an in-depth exploration of its mechanisms in diverse diseases.
Key Messages:
The goal of this review was to establish a robust theoretical foundation for a more comprehensive understanding of eccDNA, offering valuable insights for the development of clinical diagnostics and innovative therapeutic strategies in the context of related diseases.
Related Concept Videos
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon...
Epigenetic Regulation
X-chromosome...
DNA Helicases
Chromosome Structure
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
CRISPR
Genome Copying Errors

