Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

10.7K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.7K
Specialized Care Centers and Settings-II01:30

Specialized Care Centers and Settings-II

717
Rural Health Centers
Rural health centers are specialized care facilities in remote locations with very few medical personnel. The primary care providers who run the centers are mostly Registered Nurse Practitioners. Here, emergency treatment is provided to critically ill or injured patients before they are transferred to the closest hospital. Fortunately, due to advancement in technology, many rural healthcare facilities and professionals have easy access to diagnostic and treatment...
717
Blood Transfusion01:15

Blood Transfusion

526
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
526
Standard Precaution01:26

Standard Precaution

1.9K
Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
1.9K
Pre-Procedural Guidelines for Assessing Blood Pressure01:10

Pre-Procedural Guidelines for Assessing Blood Pressure

524
Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
524

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expanding access to prehospital blood products: a narrative review of clinical evidence, systems barriers, and statewide strategies.

Trauma surgery & acute care open·2026
Same author

Introducing Technology for Bedside Nurses: A New Department for Critical Care Practice.

Critical care nurse·2026
Same author

Establishing the Standardized EMS Metrics for Survival in Transfusion and Advanced Resuscitation: the SEMSTAR project.

Trauma surgery & acute care open·2026
Same author

Prehospital blood transfusion coalition core competencies for emergency medical services personnel.

Trauma surgery & acute care open·2026
Same author

Tactical transfusion-Importance and logistics of integrating prehospital blood in tactical EMS operations.

Transfusion·2026
Same author

Evaluating reimbursement for prehospital blood transfusions: A nationwide survey.

Transfusion·2025

Related Experiment Video

Updated: Jun 11, 2025

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

16.0K

Low-Titer O-Positive Whole Blood: Lessons From the Battlefield for Civilian Rural Hospitals.

Sean O'Hollearn1, Randall Schaefer2, Cassandra DuBose3

  • 1Capt Sean O'Hollearn, USAF, is a critical care nurse, Walter Reed National Military Medical Center, Bethesda, Maryland.

Critical Care Nurse
|September 30, 2024
PubMed
Summary

Low-titer O-positive whole blood is a safe and effective treatment for hemorrhagic shock, proven by military use and now expanding in civilian trauma centers. Implementing this therapy in rural hospitals offers significant benefits for patient care and trauma systems.

More Related Videos

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
05:58

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes

Published on: March 22, 2022

4.0K
Isolation and Cryopreservation of Highly Viable Human Peripheral Blood Mononuclear Cells From Whole Blood: A Guide for Beginners
10:48

Isolation and Cryopreservation of Highly Viable Human Peripheral Blood Mononuclear Cells From Whole Blood: A Guide for Beginners

Published on: October 25, 2024

3.0K

Related Experiment Videos

Last Updated: Jun 11, 2025

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

16.0K
Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
05:58

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes

Published on: March 22, 2022

4.0K
Isolation and Cryopreservation of Highly Viable Human Peripheral Blood Mononuclear Cells From Whole Blood: A Guide for Beginners
10:48

Isolation and Cryopreservation of Highly Viable Human Peripheral Blood Mononuclear Cells From Whole Blood: A Guide for Beginners

Published on: October 25, 2024

3.0K

Area of Science:

  • Emergency Medicine
  • Trauma Surgery
  • Transfusion Medicine

Background:

  • Low-titer O-positive whole blood (LTOWB) has been successfully utilized by the military in combat zones for managing hemorrhagic shock.
  • Its established safety and efficacy in trauma care have led to its adoption as the standard of care within the US military.
  • Recent civilian research validates the benefits of LTOWB, prompting its wider implementation in trauma centers nationwide.

Purpose of the Study:

  • To highlight the advantages of adopting low-titer O-positive whole blood in rural hospital settings.
  • To discuss the benefits of LTOWB for patients, healthcare staff, and the broader trauma system.
  • To encourage the expansion of LTOWB use beyond major trauma centers to rural environments.

Main Methods:

  • Review of military and civilian studies on the use of low-titer O-positive whole blood.
  • Analysis of the safety and efficacy data supporting LTOWB in hemorrhagic shock management.
  • Description of the practical benefits and implementation considerations for rural trauma centers.

Main Results:

  • Low-titer O-positive whole blood is consistently shown to be feasible, safe, and effective for trauma patients with hemorrhagic shock.
  • Widespread adoption in over 80 US trauma centers demonstrates successful integration into civilian emergency care.
  • The military's experience provides a strong evidence base for the clinical utility of LTOWB.

Conclusions:

  • Low-titer O-positive whole blood represents a critical advancement in the treatment of hemorrhagic shock.
  • Expanding LTOWB use to rural hospitals can enhance patient outcomes and strengthen regional trauma care.
  • The benefits extend to improved staff preparedness and more resilient trauma systems.